Found 3 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [T790M,L858R]' and Ligand = 'BDBM5447' TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals
US Patent
Betta Pharmaceuticals
US Patent
Affinity DataIC50: 412nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals
US Patent
Betta Pharmaceuticals
US Patent
Affinity DataIC50: 3.10E+3nMpH: 7.5 T: 2°CAssay Description:FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Betta Pharmaceuticals
US Patent
Betta Pharmaceuticals
US Patent
Affinity DataIC50: 3.40E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
