Found 7 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50565738' TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human TRKA by Z-LYTE or ADP-Glo assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Inhibition of LMNA fused TRKA G595R mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: <30nMAssay Description:Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in AKT phosphorylation at S473 residue after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: <30nMAssay Description:Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in AKT phosphorylation at T308 residue after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: <30nMAssay Description:Inhibition of TRKA in human KM-12-LUC cells assessed as reduction in ERK1/2 phosphorylation at T202/Y204 residues after 2 hrs by Western blot analysi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Inhibition of TEL fused wild type TRKA (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue afte...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 67nMAssay Description:Inhibition of LMNA fused TRKA G667C mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y490 residue ...More data for this Ligand-Target Pair
