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Found 5 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM50322422'
TargetHistone deacetylase 8(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  120nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of recombinant full-length HDAC8 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC8 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Schistosoma mansoni)
Washington University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of full length human recombinant KDAC8 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed