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Found 5 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM48009'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8...)
Affinity DataKi:  161nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8...)
Affinity DataIC50:  534nMAssay Description:Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8...)
Affinity DataIC50:  550nMAssay Description:Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(8-fluoranylindolo[2,1-b]quinazoline-6,12-dione | 8...)
Affinity DataKd:  4.68E+4nMAssay Description:Binding affinity to human IDO1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed