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Found 11 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-5' and Ligand = 'BDBM50235980'
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]Echistatin from human placental integrin alpha-V-beta-5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-5 receptor by solid phase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]echistatin from AlphaVbeta5 integrin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]-echistatin from alpha-v-beta-5 integrin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity to Integrin alpha-v-beta-5 receptor by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of vitronectin binding to Integrin alphaVbeta5 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of vitronectin binding to recombinant human integrin alphaV (Phe31 to Val992 residues) beta5 (Gly24 to Asn719 residues) expressed in CHO c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of vitronectin binding to human alphaVbeta5 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Department Of Organic Chemistry Ugo Schiff University Of Firenze Via Della Lastruccia 13

Curated by ChEMBL
LigandPNGBDBM50235980(2-((2S,5R,8S,11S)-5-benzyl-11-(3-guanidinopropyl)-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Binding affinity to alphaVbeta5 integrin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed