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Found 5 Enz. Inhib. hit(s) with Target = 'Lysyl oxidase homolog 2' and Ligand = 'BDBM50232685'
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: <300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50:  999nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed