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Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM414184'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414184(US10435369, Example 71)
Affinity DataIC50:  4nMAssay Description:Inverse agonist activity of potential ligands to RORγ was measured by inhibition of luminescence in a Gal4-luciferase reporter assay in Jurkat c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414184(US10435369, Example 71)
Affinity DataEC50:  8.70E+4nMAssay Description:Inverse agonist activity at RORgammat in CD3/CD28-stimulated human whole blood assessed as suppression of IL17 incubated for 1 hr before CD3/CD28 sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM414184(US10435369, Example 71)
Affinity DataEC50:  4.00E+3nMAssay Description:Inverse agonist activity at human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells incubated for 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed