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Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50050117'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50050117(CHEMBL3317843 | US9216988, 54)
Affinity DataIC50:  30nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50050117(CHEMBL3317843 | US9216988, 54)
Affinity DataEC50:  270nMAssay Description:Agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50050117(CHEMBL3317843 | US9216988, 54)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed