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Found 2 Enz. Inhib. hit(s) with Target = 'Plasma kallikrein' and Ligand = 'BDBM423187'
TargetPlasma kallikrein(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423187(N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyr...)
Affinity DataKi:  0.5nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Rattus norvegicus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423187(N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyr...)
Affinity DataIC50:  1nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent