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Found 3 Enz. Inhib. hit(s) with Target = 'Plasminogen activator inhibitor 1' and Ligand = 'BDBM92485'
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
University of Michigan

US Patent
LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataIC50:  10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
University of Michigan

US Patent
LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
University of Michigan

US Patent
LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed