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Found 17 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM50388686'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  2nMAssay Description:Inhibition of human ERG potassium channel transfected in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  13nMAssay Description:Inhibition of hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  15nMAssay Description:Inhibition of human ERK potassium channel by automated patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  17nMAssay Description:Inhibition of hERG channel expressed in HEK293 cells at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  22nMAssay Description:Inhibition of human ERG potassium channel expressed in CHO cells by automated patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  31nMAssay Description:Inhibition of human ERG potassium channel by manual patch-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  32nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  32nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  56nMAssay Description:Inhibition of hERG expressed in CHO cells at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  70nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential measured after 3 mins by QPatch automated patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  80nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  150nMAssay Description:Inhibition of human ERG expressed in CHO cells by Qpatch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  170nMAssay Description:Inhibition of hERG channel assessed as prolongation of QT interval by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  190nMAssay Description:Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  270nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of human ERG channel by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of hERG expressed in CHO cells Qpatch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed