Found 259 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 1' and Ligand = 'BDBM11639' TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 0.700nMAssay Description:Tested for inhibition against Prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 13nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 50nMAssay Description:In vitro potency against human Prostaglandin G/H synthase 1 in U937 microsomes .More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 50nMAssay Description:Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 125nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid as substrate pretreated for 10 mins followed by substrate addition measured after 2 mins b...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 132nMAssay Description:Inhibition of human recombinant COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 300nMAssay Description:Inhibition of human COX1 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 10 mins follo...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 410nMAssay Description:Inhibition of COX1 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate incubated for 5 mins by fluorescence-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human COX1 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ovine COX1 by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human cyclooxygenase-1 expressed in COS cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 treated 1 hr before a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 1.88E+3nMAssay Description:In vitro inhibition of cyclooxygenase-1 by inhibition of TXB2 generation with 1 uM arachidonic acid in human plateletsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COX-1 in human whole blood assessed as thromboxane B2 level in serum after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of COX1 in arachidonic acid-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challeng...More data for this Ligand-Target Pair
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to s...More data for this Ligand-Target Pair
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate preincubated for 15 mins followed substrate addition and assessed as inhib...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of ovine purified COX1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.98E+3nMAssay Description:Ability to inhibit Prostaglandin G/H synthase 1 by using freshly harvested mouse peritoneal macrophagesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.98E+3nMAssay Description:In vitro inhibitory activity against prostaglandin G/H synthase 1 using mouse peritoneal macrophage methodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 5.10E+3nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of COX1-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphomaMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of ovine COX-1 by EIA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.57E+3nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme i...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 6.12E+3nMAssay Description:Inhibition of recombinant human COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tehran University Of Medical Sciences
Curated by ChEMBL
Tehran University Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 6.30E+3nMAssay Description:In vitro potency against human Prostaglandin G/H synthase 1 (hCOX-1) in the human whole blood assay.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory concentration of the compound was measured against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
