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Found 4 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM50289303'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:In vivo ability of the compound to inhibit cyclooxygenase-1 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human COX2 expressed in CHO cells assessed as reduction in arachidonic acid-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human COX-2 transfected in CHO cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  900nMAssay Description:In vivo ability of the compound to inhibit cyclooxygenase-2 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article