Compile Data Set for Download or QSAR
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Found 3 Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM16182'
LigandPNGBDBM16182((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mammalian FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16182((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-ras protein by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16182((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Affinity DataIC50:  200nMAssay Description:Inhibition of mammalian H-Ras processing in NIH 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed