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Found 6 Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50098002'
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataIC50:  15nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.33E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells without GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098002(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)
Affinity DataEC50:  1.98E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells at without GGT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed