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Found 3 Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM22108'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
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LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Industrial Research

LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  191nM ΔG°:  -38.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed