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Found 3 Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50312754'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50:  333nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)
Affinity DataIC50:  357nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed