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Found 11 Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM50449547'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human FLT3 by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FLT3 D835Y mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  7nMAssay Description:Inhibition of human FLT3 F594_R595insR mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human FLT3 R595_E596 mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of human FLT3 F594_R595insREY mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  13nMAssay Description:Inhibition of human FLT3 ITD-W51 mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  15nMAssay Description:Inhibition of human FLT3 ITD-NPOS mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50:  15nMAssay Description:Inhibition of human FLT3 Y591-V592 mutant by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to human FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  13nMAssay Description:Binding affinity to human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed