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Found 5 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1' and Ligand = 'BDBM163433'
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  3.90E+3nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Rattus norvegicus (Rat))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.10E+4nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.96E+4nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 70 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.96E+4nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 70 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataKd:  155nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent