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Found 2 Enz. Inhib. hit(s) with Target = 'Smoothened homolog' and Ligand = 'BDBM50113484'
TargetSmoothened homolog(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113484(CHEMBL3604610)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human Smo expressed in human U2OS cells assessed as reduction in BODIPY-cyclopamine fluorescence signaling by competitive displacement ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113484(CHEMBL3604610)
Affinity DataIC50:  64nMAssay Description:Inhibition of SMO in mouse NIH/3T3 cells assessed as inhibition of SAG-induced hedgehog-mediated luminescence signaling by GRE-luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed