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Found 3 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM429511'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429511(N-(cyclopropylsulfonyl)-3-(4-(difluoromethyl)pheny...)
Affinity DataIC50:  69nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429511(N-(cyclopropylsulfonyl)-3-(4-(difluoromethyl)pheny...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429511(N-(cyclopropylsulfonyl)-3-(4-(difluoromethyl)pheny...)
Affinity DataIC50:  321nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent