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Found 13 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 4' and Ligand = 'BDBM50158348'
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  34nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  151nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  151nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  151nMAssay Description:Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  7.90nMAssay Description:Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  37nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  270nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  164nMAssay Description:Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  270nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed