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Found 6 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50321851'
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor expressed in human 1321 cells assessed as inhibition of capsaicin-induced in intracellular ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50:  180nMAssay Description:The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA sup...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50:  180nMAssay Description:The functional activity of compounds at the TRPV1 receptor was determined by measurement of intracellular Ca2+ levels ([Ca2]i) using the Fluorescence...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human TRPV1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed