Found 8 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM50521316' TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 uM ATP by microplate reader assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Roche Innovation Center Shanghai
Curated by ChEMBL
Roche Innovation Center Shanghai
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTK in anti-CD3/CD28-stimulated human CD4-positive T cells assessed as reduction in cell proliferation pretreated for 30 mins followed ...More data for this Ligand-Target Pair
