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Found 9 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50076185'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human SYK using 5-Fluo-Ahx-GAPDYENLQELNKK-Amid as substrate in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  14nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in anti IgM-induced phosphorylation of BLNK by flow cytometry assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  35nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  35nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  99nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  99nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  367nMAssay Description:Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes assessed as phospho-SLP76 level preincubated for 30 mins followed by anti-CD32 stimul...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50:  367nMAssay Description:Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataKd:  0.640nMAssay Description:Competitive binding affinity to human SYKMore data for this Ligand-Target Pair