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Found 2 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11 [E76Z]' and Ligand = 'BDBM608845'
TargetTyrosine-protein phosphatase non-receptor type 11 [E76Z](Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM608845((3M)-6-[(3S,4S)-4-amino-3- methyl-2-oxa-8- azaspir...)
Affinity DataIC50:  21nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76Z](Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM608845((3M)-6-[(3S,4S)-4-amino-3- methyl-2-oxa-8- azaspir...)
Affinity DataIC50:  1.20E+4nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent