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Found 3 Enz. Inhib. hit(s) with Target = 'Vitamin K epoxide reductase complex subunit 1' and Ligand = 'BDBM50343352'
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  1.80E+3nM ΔG°:  -34.1kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed