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Found 67 Enz. Inhib. hit(s) with all data for entry = 50018655
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50502237(CHEMBL4470451)
Affinity DataKi:  1.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609374(CHEMBL5274383)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate assessed as inhibition constant incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610781(CHEMBL5277261)
Affinity DataKi:  4nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as a substrate assessed as inhibition constant incubated for 5 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610790(CHEMBL5287587)
Affinity DataKi:  76nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated with compound for 15 mins by microplate read...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50:  0.0130nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as diphenolase activity incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110192(3-(2,4-Dihydroxyphenyl)-1-(furan-2-yl)propenone (1...)
Affinity DataIC50:  0.0433nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as diphenolase activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50356191(CHEMBL193804)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity preincubated for 20 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610779(CHEMBL4475728)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as a substrate by UV-2450 spectrophotometeric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50276368(CHEMBL4128371)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610793(CHEMBL5286240)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610794(CHEMBL5286802)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610795(CHEMBL5289108)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610775(CHEMBL5277673)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110192(3-(2,4-Dihydroxyphenyl)-1-(furan-2-yl)propenone (1...)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610778(CHEMBL4562624)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as a substrate by UV-2450 spectrophotometeric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610783(CHEMBL4064477)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as monophenolase activity incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human his tagged tyrosinase expressed in HEK293 cells using L-DOPA as substrate by HTS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50234121(CHEMBL4069921)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated with compound for 20 mins measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609374(CHEMBL5274383)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610789(CHEMBL5284672)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610764(CHEMBL5282064)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50356191(CHEMBL193804)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate assessed as diphenolase activity preincubated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610786(CHEMBL5285434)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610769(CHEMBL5270388)
Affinity DataIC50:  2nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610774(CHEMBL4291894)
Affinity DataIC50:  2nMAssay Description:Inhibition of mushroom tyrosinase preincubated for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610780(CHEMBL5271322)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity incubated for 10 mins by microplate reader analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610766(CHEMBL5273863)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 5 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610785(CHEMBL5270398)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610768(CHEMBL5266436)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50021467(CHEMBL3289933)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610788(CHEMBL5276716)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50021465(CHEMBL3289931)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610782(CHEMBL5273032)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as diphenolase activity by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610769(CHEMBL5270388)
Affinity DataIC50:  9nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as diphenolase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610767(CHEMBL5268456)
Affinity DataIC50:  9nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610792(CHEMBL5266001)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 5 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50021417(CHEMBL3289924)
Affinity DataIC50:  10nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610763(CHEMBL5272877)
Affinity DataIC50:  10nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610776(CHEMBL5266327)
Affinity DataIC50:  11nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610765(CHEMBL5277544)
Affinity DataIC50:  13nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 5 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610784(CHEMBL5272433)
Affinity DataIC50:  14nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610773(CHEMBL1321926)
Affinity DataIC50:  15nMAssay Description:Inhibition of mushroom tyrosinase incubated for 20 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50155301(CHEMBL3781659)
Affinity DataIC50:  15nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as a substrate incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  17nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  18nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity incubated for 10 mins by microplate reader analysi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  20nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as diphenolase activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
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