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Found 11 Enz. Inhib. hit(s) with all data for entry = 50028715
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258280(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  470nMpH: 6.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258849(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  1.10E+3nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258280(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of BACE1 (unknown origin) by sAPP_NF cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258279(4-(1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nit...)
Affinity DataIC50:  3.20E+3nMpH: 6.4Assay Description:Inhibition of BACE1 at pH 6.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258278(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  3.40E+3nMpH: 6.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258278(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50:  5.70E+3nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258847(4-(1-(4-methoxyphenyl)cyclopentyl)thiazol-2-amine ...)
Affinity DataIC50:  2.50E+4nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258848(4-(1-(4-methoxyphenyl)-2-phenylethyl)thiazol-2-ami...)
Affinity DataIC50:  3.20E+4nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258846(4-(1-(4-chlorophenyl)cyclopentyl)thiazol-2-amine |...)
Affinity DataIC50:  3.80E+4nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258845(4-(1-phenylcyclopentyl)thiazol-2-amine | CHEMBL511...)
Affinity DataIC50:  2.17E+5nMpH: 4.5Assay Description:Inhibition of BACE1 (unknown origin) at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258849(4-(2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)...)
Affinity DataIC50: >2.20E+7nMAssay Description:Inhibition of BACE1 (unknown origin) by sAPP_NF cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed