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Found 42 Enz. Inhib. hit(s) with all data for entry = 50039251
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323500(CHEMBL1208999 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302841(CHEMBL571860 | N-((2S,3R)-4-(1-(3-tert-butylphenyl...)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302838(CHEMBL572081 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl...)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323493(CHEMBL1209106 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323511(CHEMBL1209894 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323498(CHEMBL1209055 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323501(CHEMBL1208998 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323509(CHEMBL1208872 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323506(CHEMBL1208933 | N-((2S,3R)-4-(1-(3-(2-cyanopropan-...)
Affinity DataIC50:  166nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323494(CHEMBL1209105 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323486(CHEMBL1209222 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323504(CHEMBL1208935 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323487(CHEMBL1209221 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323499(CHEMBL1209054 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323510(CHEMBL1208871 | N-((2S,3R)-4-(1-(3-((E)-but-2-en-2...)
Affinity DataIC50:  380nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323507(CHEMBL1208874 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323514(CHEMBL1209892 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323482(CHEMBL1209286 | N-((2S,3R)-4-(1-(3-(1,3-dioxepan-5...)
Affinity DataIC50:  560nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323480(CHEMBL1209356 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323479(CHEMBL1209357 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323512(CHEMBL1209893 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  690nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323481(CHEMBL1209355 | N-((2S,3R)-4-(1-(3-(1,4-oxazepan-4...)
Affinity DataIC50:  700nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323503(CHEMBL1208936 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  720nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323483(CHEMBL1209285 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323489(CHEMBL1209167 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323508(CHEMBL1208873 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  810nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323492(CHEMBL1209107 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  820nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323495(CHEMBL1209104 | N-((2S,3R)-4-(1-(3-cyclopentylphen...)
Affinity DataIC50:  940nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323484(CHEMBL1209284 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323502(CHEMBL1208997 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323485(CHEMBL1209223 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323491(CHEMBL1209165 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323490(CHEMBL1209166 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323497(CHEMBL1209056 | N-((2S,3R)-4-(1-(3-(1H-imidazol-1-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323478(CHEMBL1209358 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323475(CHEMBL1209420 | N-((2S,3R)-4-(1-(3-(2-azabicyclo[2...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323476(CHEMBL1209419 | N-((2S,3R)-4-(1-(3-(2-oxa-5-azabic...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323477(CHEMBL1209418 | N-((2S,3R)-4-(1-(3-(1,4-dioxan-2-y...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323505(CHEMBL1208934 | N-((2S,3R)-4-(1-(3-cyanophenyl)cyc...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323496(CHEMBL1209057 | N-((2S,3R)-4-(1-(3-(2H-1,2,3-triaz...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323488(CHEMBL1209168 | N-((2S,3R)-4-(1-(3-cyclohexylpheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323513(CHEMBL1208803 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant BACE-1 expressed in Escherichia coli after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed