Compile Data Set for Download or QSAR
maximum 50k data
Found 42 Enz. Inhib. hit(s) with all data for entry = 50013431
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565800(Azd-1390 | Azd1390)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of ATM (unknown origin) assessed as ATM-dependent phosphorylation using GST-p53 ser15 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565801(CHEMBL4780868)
Affinity DataIC50:  2.80nMAssay Description:Displacement of kinase tracer178 from recombinant WEE1 (unknown origin) incubated for 1 hr by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human CDK7 incubated for 180 mins by LanthaScreen Eu Kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of N-terminal GST-fused human WEE1 (215 to 646 residues) expressed in baculovirus expression system using poly(Lys,Tyr) as substrate incub...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565799(CHEMBL4780892)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50:  7nMAssay Description:Displacement of 5-TAMRA-labelled Tracer A from human GST-fused/FLAG-tagged full length ATR/human N-terminal FLAG-tagged full length ATRIP expressed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length Flag-tagged ATM (unknown origin) using GST-p53(1 to 101 residues) as substrates incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50208517(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human HeLa nuclear extract derived ATM using glutathioneS-transferase-p53N66 as substrate preincubated for 10 mins followed by ATP addi...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  24nMAssay Description:Inhibition of full length WEE1 (unknown origin) assessed as reduction in cdc2/cyclin B phosphorylation using biotinylated histone H1 peptide (PKTPKKA...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CDK12 (696 to 1082 residues)/human cyclinK (1 to 267 residues) using pol2 CTD-peptide substrate and [gammaP]ATP by scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50528813(CHEMBL4163879)
Affinity DataIC50:  69nMAssay Description:Inhibition of CDK13/human cyclin K expressed in baculovirus-infected insect cells using pol2 CTD-peptide substrate and [gammaP]ATP by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  90nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in radiation-induced autophosphorylation at S2056 residue preincubated for 1 hr follow...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of c-SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of MYT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of PDGFR-beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50: <100nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50528813(CHEMBL4163879)
Affinity DataIC50:  158nMAssay Description:Inhibition of human CDK12/human cyclin K expressed in baculovirus-infected insect cells using pol2 CTD-peptide substrate and [gammaP]ATP by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  225nMAssay Description:Inhibition of CDK13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  277nMAssay Description:Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  500nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  570nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  864nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  970nMAssay Description:Inhibition of PI3K beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50436204(CHEMBL109037)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565810(Strictinin)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50187665((-)-epigallocatechin | CHEMBL47386)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565798(CHEMBL4789596)
Affinity DataIC50:  2.96E+3nMAssay Description:Inhibition of human HeLa nuclear extract derived ATM using glutathioneS-transferase-p53N66 as substrate preincubated for 10 mins followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565806(CHEMBL4795092)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565807(CHEMBL4785174)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565808(CHEMBL4785369)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565809(CHEMBL1718911)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human RAD52 assessed as reduction in DNA annealing using tailed ds-DNA 337-F/1337-BHQ1 by fluorescence-quenching assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565805(CHEMBL4785153)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565804(CHEMBL4796552)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565803(CHEMBL4777728)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565802(CHEMBL4165444 | US11584714, Compound 29)
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565800(Azd-1390 | Azd1390)
Affinity DataIC50:  6.55E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM48804(3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...)
Affinity DataIC50:  2.74E+4nMAssay Description:Inhibition of human RAD51 using 90-mer ssDNA as substrate measured after 30 mins by D-loop assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50: >3.33E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed