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Found 27 Enz. Inhib. hit(s) with all data for entry = 50015878
TargetNeutrophil collagenase(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM88417(MLS000109417 | S-[2-(3,4-dichloroanilino)-2-oxoeth...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50542679(CHEMBL4639584)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590254(CHEMBL5187403)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590263(CHEMBL5180620)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590255(CHEMBL5177773)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590257(CHEMBL5178843)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590264(CHEMBL5186991)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590265(CHEMBL1330520)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50303400(CHEMBL577546 | S-2-(3-chlorophenylamino)-2-oxoethy...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590259(CHEMBL5197727)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590256(CHEMBL5176746)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590260(CHEMBL5189927)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590267(CHEMBL5180526)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590258(CHEMBL5188593)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590253(CHEMBL1993867)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590266(CHEMBL5169714)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590268(CHEMBL5173990)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590261(CHEMBL5173122)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50590262(CHEMBL5204419)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50542711(CHEMBL4640494)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetElastase(Pseudomonas aeruginosa)
Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM50589974(CHEMBL5186191)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PA14 LasB elastase preincubated for 15 mins followed by substrate addition and measured after 60 mins using 2-am...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed