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Found 12 Enz. Inhib. hit(s) with all data for entry = 50015724
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human Cav2.2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435904(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  6.40nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435762(2-(2,6-dichlorophenyl)-1- ((1S,3R)-5-(1-ethyl-1H- ...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435774(1-((1S,3R)-5-(1-cyclopropyl- 1H-pyrazol-4-yl)-3- (...)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435778(2-(2,6-dichlorophenyl)-1- ((1S,3R)-3-(hydroxymethy...)
Affinity DataEC50:  26nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human 5HT2bMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  3.20E+3nMAssay Description:Induction of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  151nMAssay Description:Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1B) dopamine receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  480nMAssay Description:Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1B) dopamine receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM435739(2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl...)
Affinity DataEC50:  12nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  5.50E+3nMAssay Description:Induction of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed