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Target
Rho-associated protein kinase 2 [1-552]
Ligand
BDBM598666
Substrate
n/a
Meas. Tech.
Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay)
IC50
1.70±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent  US11613531 Publication Date 3/28/2023 
Target
Name:
Rho-associated protein kinase 2 [1-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme
Mol. Mass.:
63353.50
Organism:
Homo sapiens (Human)
Description:
aa 1-552
Residue:
552
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM598666
Synonyms:
2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chloro-N4-(1H-indazol-5-yl)-N6,N6-dimethylpyrimidine-4,6-diamine | US11613531, Example 344
Type:
Small organic molecule
Emp. Form.:
C19H23ClN8
Mol. Mass.:
398.893
SMILES:
CN(C)c1nc(nc(Nc2ccc3[nH]ncc3c2)c1Cl)N1C2CCC1CNC2
Structure:
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