Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM118660
Substrate
n/a
Meas. Tech.
Human Orexin 1 Receptor Radioligand Binding Studies
Ki
128±n/a nM
Citation
 Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Johnson, AS; Stocking, EM; Swanson, DM Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators US Patent  US11667644 Publication Date 6/6/2023 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM118660
Synonyms:
US11059828, Example 313 | US11667644, Example 313 | US8653263, 313 | US9586962, Example 313 | USRE48841, Example 313
Type:
Small organic molecule
Emp. Form.:
C23H24FN7O
Mol. Mass.:
433.4814
SMILES:
Cc1nc(nc2CCCc12)N1CC2CN(CC2C1)C(=O)c1c(F)cccc1-n1nccn1
Structure:
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