Reaction Details Report a problem with these data
Target
Chromatin remodeling regulator CECR2 [424-538]
Ligand
BDBM310908
Substrate
n/a
Meas. Tech.
CECR2 TR-FRET Binding Assay
IC50
240±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, AF; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10150767 Publication Date 12/11/2018 
Target
Name:
Chromatin remodeling regulator CECR2 [424-538]
Synonyms:
CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13747.10
Organism:
Homo sapiens (Human)
Description:
Q9BXF3[424-538]
Residue:
115
Sequence:
MREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKH
  
Inhibitor
Name:
BDBM310908
Synonyms:
6-methyl-4-(4-(4-methyl-3-oxopiperazine-1-carbonyl)phenyl)-1H-pyrrolo[2,3-c]pyridin-7(6H)-one | US10150767, Example 26
Type:
Small organic molecule
Emp. Form.:
C20H20N4O3
Mol. Mass.:
364.3978
SMILES:
CN1CCN(CC1=O)C(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
Structure:
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