Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340222
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent  US9758537 Publication Date 9/12/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM340222
Synonyms:
(2S)-1-(2-(3-acetyl-6- hydroxy-1H-indol-1- yl)acetyl)-N-(3-chloro- 2-fluorobenzyl)-3- (cyclopropylmethoxy)- 4-fluoropyrrolidine-2- carboxamide | US9758537, Compound 25
Type:
Small organic molecule
Emp. Form.:
C28H28ClF2N3O5
Mol. Mass.:
559.989
SMILES:
CC(=O)c1cn(CC(=O)N2CC(F)C(OCC3CC3)[C@H]2C(=O)NCc2cccc(Cl)c2F)c2cc(O)ccc12 |r|
Structure:
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