Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340272
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM340272
Synonyms:
(2S,4R)-1-(2-(3-(1H- imidazol-5-yl)-1H- pyrazolo[3,4-c]pyridin- 1-yl)acetyl)-N-(3- chloro-2-fluorobenzyl)- 4-fluoropyrrolidine-2- carboxamide | US9758537, Compound 75
Type:
Small organic molecule
Emp. Form.:
C23H20ClF2N7O2
Mol. Mass.:
499.9
SMILES:
F[C@@H]1C[C@H](N(C1)C(=O)Cn1nc(-c2cnc[nH]2)c2ccncc12)C(=O)NCc1cccc(Cl)c1F |r|