Reaction Details Report a problem with these data
Target
Lysine-specific demethylase 4C
Ligand
BDBM296165
Substrate
n/a
Meas. Tech.
JMJD2C Assay
IC50
<100±n/a nM
Citation
 Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Histone demethylase inhibitors US Patent  US10202381 Publication Date 2/12/2019 
Target
Name:
Lysine-specific demethylase 4C
Synonyms:
GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780
Type:
Protein
Mol. Mass.:
119979.01
Organism:
Homo sapiens (Human)
Description:
Q9H3R0
Residue:
1056
Sequence:
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
  
Inhibitor
Name:
BDBM296165
Synonyms:
2-[4-[N-methyl-3-(4-methyl-1,4-diazepan- 1-yl)anilino]phenoxy]pyrido[3,4- d]pyrimidin-4-ol | US10112940, Example 88 | US10202381, Example 88 | US10208039, Example 88 | US10611763, Example 88 | US10815234, Example 88 | US11535616, Example 88
Type:
Small organic molecule
Emp. Form.:
C26H28N6O2
Mol. Mass.:
456.5395
SMILES:
CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1cccc(c1)N1CCCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: