Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM26447
Substrate
BDBM26431
Meas. Tech.
MurD Inhibition Assay
pH
8.6±n/a
Temperature
310.15±n/a K
IC50
192000±n/a nM
Citation
Humljan, J; Kotnik, M; Contreras-Martel, C; Blanot, D; Urleb, U; Dessen, A; Solmajer, T; Gobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem 51:7486-94 (2008) [PubMed] Article
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
Inhibitor
Name:
BDBM26447
Synonyms:
(2R)-2-{[6-(2-ethoxy-2-oxoethoxy)naphthalene-2-]sulfonamido}pentanedioic acid | naphthalene-N-sulfonyl-D-glu derivative, 17f
Type:
Small organic molecule
Emp. Form.:
C19H21NO9S
Mol. Mass.:
439.436
SMILES:
CCOC(=O)COc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H](CCC(O)=O)C(O)=O |r|