Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM50268222
Substrate
n/a
Meas. Tech.
ChEMBL_1704986 (CHEMBL4056219)
IC50
9.6±n/a nM
Citation
 Hirose, H; Yamasaki, T; Ogino, M; Mizojiri, R; Tamura-Okano, Y; Yashiro, H; Muraki, Y; Nakano, Y; Sugama, J; Hata, A; Iwasaki, S; Watanabe, M; Maekawa, T; Kasai, S Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus. Bioorg Med Chem 25:4175-4193 (2017) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM50268222
Synonyms:
CHEMBL4063587
Type:
Small organic molecule
Emp. Form.:
C28H34FN3O5
Mol. Mass.:
511.5851
SMILES:
CCOc1cc(CN2CC3(C2)CC(=NO3)N2CCC(CC2)C(O)=O)cc(OCC)c1-c1ccc(F)cc1 |c:13|
Structure:
Search PDB for entries with ligand similarity: