Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM50268447
Substrate
n/a
Meas. Tech.
ChEMBL_1704986 (CHEMBL4056219)
IC50
30±n/a nM
Citation
 Hirose, H; Yamasaki, T; Ogino, M; Mizojiri, R; Tamura-Okano, Y; Yashiro, H; Muraki, Y; Nakano, Y; Sugama, J; Hata, A; Iwasaki, S; Watanabe, M; Maekawa, T; Kasai, S Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus. Bioorg Med Chem 25:4175-4193 (2017) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM50268447
Synonyms:
CHEMBL4072189
Type:
Small organic molecule
Emp. Form.:
C29H35FN2O5
Mol. Mass.:
510.597
SMILES:
CCOc1cc(CN2CC3(C2)CC(=NO3)[C@H]2CC[C@@H](CC2)C(O)=O)cc(OCC)c1-c1ccc(F)cc1 |r,wU:18.23,wD:15.16,c:13,(44.48,-26.9,;44.48,-25.36,;45.82,-24.59,;45.82,-23.05,;44.48,-22.28,;44.48,-20.73,;43.15,-19.96,;41.82,-20.74,;40.33,-20.33,;39.93,-21.81,;41.42,-22.22,;38.59,-21.04,;37.45,-22.08,;38.08,-23.49,;39.61,-23.32,;35.94,-21.76,;35.47,-20.29,;33.97,-19.97,;32.93,-21.12,;33.41,-22.58,;34.92,-22.91,;31.43,-20.79,;30.39,-21.93,;30.95,-19.33,;45.81,-19.96,;47.15,-20.73,;48.48,-19.95,;48.47,-18.41,;49.8,-17.64,;47.15,-22.28,;48.48,-23.04,;48.48,-24.59,;49.82,-25.35,;51.15,-24.58,;52.49,-25.35,;51.14,-23.03,;49.81,-22.27,)|
Structure:
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