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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50477753
Substrate
n/a
Meas. Tech.
ChEMBL_458618 (CHEMBL941947)
Ki
1995±n/a nM
Citation
 Heightman, TD; Scott, JS; Longley, M; Bordas, V; Dean, DK; Elliott, R; Hutley, G; Witherington, J; Abberley, L; Passingham, B; Berlanga, M; de Los Frailes, M; Wise, A; Powney, B; Muir, A; McKay, F; Butler, S; Winborn, K; Gardner, C; Darton, J; Campbell, C; Sanger, G Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. Bioorg Med Chem Lett 17:6584-7 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50477753
Synonyms:
CHEMBL399704
Type:
Small organic molecule
Emp. Form.:
C22H28BrN3O3S
Mol. Mass.:
494.445
SMILES:
COc1cc2CCN(c2cc1N1C[C@H](C)N(C)[C@H](C)C1)S(=O)(=O)c1cccc(Br)c1
Structure:
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