Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50479053
Substrate
n/a
Meas. Tech.
ChEMBL_509633 (CHEMBL1003961)
IC50
25000±n/a nM
Citation
 Zeng, LF; Jiang, XH; Sanchez, T; Zhang, HS; Dayam, R; Neamati, N; Long, YQ Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation. Bioorg Med Chem 16:7777-87 (2008) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50479053
Synonyms:
CHEMBL464340
Type:
Small organic molecule
Emp. Form.:
C26H20F6N2O6
Mol. Mass.:
570.4372
SMILES:
FC(F)(F)c1ccc(cc1)C(=O)CC(=O)C(=O)N1CCN(CC1)C(=O)C(=O)CC(=O)c1ccc(cc1)C(F)(F)F
Structure:
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