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Target
RNA-directed RNA polymerase
Ligand
BDBM50495957
Substrate
n/a
Meas. Tech.
ChEMBL_1293306 (CHEMBL3123718)
IC50
>100000±n/a nM
Citation
 Du, J; Chun, BK; Mosley, RT; Bansal, S; Bao, H; Espiritu, C; Lam, AM; Murakami, E; Niu, C; Micolochick Steuer, HM; Furman, PA; Sofia, MJ Use of 2'-spirocyclic ethers in HCV nucleoside design. J Med Chem 57:1826-35 (2014) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
2.7.7.48 | NS5b | RNA-directed RNA polymerase
Type:
PROTEIN
Mol. Mass.:
65779.30
Organism:
Hepacivirus C
Description:
ChEMBL_118447
Residue:
591
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM50495957
Synonyms:
CHEMBL3121492
Type:
Small organic molecule
Emp. Form.:
C11H18N3O14P3
Mol. Mass.:
509.1936
SMILES:
Nc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]22CCO2)c(=O)n1 |r|
Structure:
Search PDB for entries with ligand similarity: