Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50510966
Substrate
n/a
Meas. Tech.
ChEMBL_1842715 (CHEMBL4343142)
Ki
2.4±n/a nM
Citation
 Wan, Y; Li, Y; Yan, C; Yan, M; Tang, Z Indole: A privileged scaffold for the design of anti-cancer agents. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50510966
Synonyms:
CHEMBL4457559
Type:
Small organic molecule
Emp. Form.:
C37H35Cl2N5O6S
Mol. Mass.:
748.675
SMILES:
Cc1n[nH]c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)NS(=O)(=O)c1ccc(o1)C(=O)NCc1ccccc1 |(8.24,-21.23,;9.7,-21.7,;10.18,-23.17,;11.72,-23.17,;12.2,-21.7,;13.66,-21.22,;10.94,-20.79,;10.94,-19.25,;9.61,-18.48,;8.27,-19.25,;9.61,-16.94,;10.94,-16.17,;12.27,-16.93,;13.74,-16.45,;13.73,-14.9,;15.06,-14.12,;15.04,-12.58,;16.37,-11.8,;16.36,-10.26,;15.03,-9.52,;15.01,-7.98,;13.67,-7.22,;16.34,-7.19,;16.33,-5.65,;17.68,-7.95,;19.01,-7.17,;17.69,-9.49,;14.65,-17.69,;13.75,-18.94,;12.28,-18.48,;16.19,-17.68,;16.96,-16.34,;16.97,-19.01,;16.21,-20.35,;14.87,-21.11,;14.88,-19.57,;16.99,-21.68,;16.37,-23.09,;17.52,-24.12,;18.85,-23.34,;18.52,-21.83,;20.39,-23.33,;21.15,-22,;21.16,-24.66,;20.39,-26,;21.17,-27.33,;20.39,-28.66,;21.16,-29.99,;22.71,-29.99,;23.47,-28.65,;22.7,-27.32,)|
Structure:
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