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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50511364
Substrate
n/a
Meas. Tech.
ChEMBL_1844742 (CHEMBL4345169)
IC50
400±n/a nM
Citation
 Rajapaksa, NS; Gobbi, A; Drobnick, J; Do, S; Kolesnikov, A; Liang, J; Chen, Y; Sujatha-Bhaskar, S; Huang, Z; Brightbill, H; Francis, R; Yu, C; Choo, EF; DeMent, K; Ran, Y; An, L; Emson, C; Maher, J; Wai, J; McKenzie, BS; Lupardus, PJ; Zarrin, AA; Kiefer, JR; Bryan, MC Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett 11:327-333 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50511364
Synonyms:
CHEMBL4466517 | US10988478, Example 31
Type:
Small organic molecule
Emp. Form.:
C21H23N5O4
Mol. Mass.:
409.4384
SMILES:
C[C@]1(CO)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCOCC1 |r|
Structure:
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