Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50067417
Substrate
n/a
Meas. Tech.
ChEMBL_31797 (CHEMBL643203)
IC50
5000±n/a nM
Citation
 Negoro, T; Murata, M; Ueda, S; Fujitani, B; Ono, Y; Kuromiya, A; Komiya, M; Suzuki, K; Matsumoto, J Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem 41:4118-29 (1998) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase
Type:
PROTEIN
Mol. Mass.:
35865.31
Organism:
Sus scrofa
Description:
ChEMBL_502637
Residue:
316
Sequence:
MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYPFHEEY
  
Inhibitor
Name:
BDBM50067417
Synonyms:
CHEMBL133737 | [Methyl-(1H-pyrrole-2-carbonyl)-amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C8H10N2O3
Mol. Mass.:
182.1766
SMILES:
CN(CC(O)=O)C(=O)c1ccc[nH]1
Structure:
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