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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM50085153
Substrate
n/a
Meas. Tech.
ChEMBL_155539 (CHEMBL759744)
IC50
11000±n/a nM
Citation
 Martínez, A; Castro, A; Gil, C; Miralpeix, M; Segarra, V; Doménech, T; Beleta, J; Palacios, JM; Ryder, H; Miró, X; Bonet, C; Casacuberta, JM; Azorín, F; Piña, B; Puigdoménech, P Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors. J Med Chem 43:683-9 (2000) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM50085153
Synonyms:
4-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-3,3-dioxo-3,4-dihydro-2H-3lambda*6*,9-dithia-2,4-diaza-fluoren-1-one | CHEMBL159801
Type:
Small organic molecule
Emp. Form.:
C18H14N2O5S2
Mol. Mass.:
402.444
SMILES:
COc1ccc(cc1)C(=O)CN1c2c(sc3ccccc23)C(=O)NS1(=O)=O
Structure:
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