Reaction Details
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GTPase KRas
Ligand
BDBM50539752
Substrate
n/a
Meas. Tech.
ChEMBL_1979212 (CHEMBL4612347)
IC50
4840±n/a nM
Citation
Fell, JB; Fischer, JP; Baer, BR; Blake, JF; Bouhana, K; Briere, DM; Brown, KD; Burgess, LE; Burns, AC; Burkard, MR; Chiang, H; Chicarelli, MJ; Cook, AW; Gaudino, JJ; Hallin, J; Hanson, L; Hartley, DP; Hicken, EJ; Hingorani, GP; Hinklin, RJ; Mejia, MJ; Olson, P; Otten, JN; Rhodes, SP; Rodriguez, ME; Savechenkov, P; Smith, DJ; Sudhakar, N; Sullivan, FX; Tang, TP; Vigers, GP; Wollenberg, L; Christensen, JG; Marx, MA Identification of the Clinical Development Candidate J Med Chem 63:6679-6693 (2020) [PubMed] Article More Info.:
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM50539752
Synonyms:
CHEMBL4638484
Type:
Small organic molecule
Emp. Form.:
C32H40N6O3
Mol. Mass.:
556.6984
SMILES:
CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN(CC1CCO)C(=O)C=C)c1cccc2ccccc12 |r|
Structure:
